At Fraunhofer IMS all necessary technologies for the development and production of miniaturized biosensors are available. Special sensitive surface structures, for example the µm-thin membrane of a mass-sensitive biosensor can be manufactured using state-of-the-art micro- and nanotechnological processes in the in-house clean rooms in 0.35 µm Technology. The functionalization of the biosensors with a biological receptor is carried out in the in-house biolab of the business unit Biohybrid Systems.
For the characterization of the developed biosensors there is a broad spectrum of different analysis devices available in our biolab. This includes molecular diagnostic analysis devices for carrying out biochemical assays, for example enzyme-linked immunosorbent assay (ELISA). Moreover, the surface of functionalized biosensors can be characterized, e.g. using fluorescence microscopy, atomic force microscopy (AFM) and surface plasmon resonance spectroscopy (SPR spectroscopy). Thus, the biosensors can be evaluated with standardized analysis processes that are established in industrial research.
To convert the detection signal of the biosensor into an electrical signal, application-specific integrated circuits (ASICs) can be realized at Fraunhofer IMS using semiconductor technologies. This way, miniaturized biosensors can be manufactured which are suited for the integration into compact systems. In addition, the cost-efficient production processes allow for the developed biosensors to be applied in single-use applications. For the integration of biosensors into sealed (e.g. bioreactors, implants) or for the mobile use designed systems, the energy and data transfer can be carried out via the wireless communication technologies developed at Fraunhofer IMS.